The fluorescence study of the quenching of nanoemulsion by protoporphyrin IX (PPIX)

Nanoemulsion is a unique and versatile fluid that solubilizes both ionic non-ionic molecules. It has been used extensively for drug delivery. Nanoemulsion, prepared with water-oil-surfactant co-surfactant, fluorescent at or the near IR region of electromagnetic spectrum. However, when protoporphyrin (PPIX), useful photosensitizer in PDT modality, poorly water-soluble compound, introduced into nanoemulsion medium, observed fluorescence quenched. We have steady-state technique to study mechanism this quenching. interaction between PPIX 1:1 constant, Ka, about 2.37 x 105/mol Free energy interactions, Ga, -30.66 kJ/mol.